Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease

Vitiligo is one of the most well-known conditions of skin depigmentation. It is estimated to occur in up to 2% of the world’s population. A number of people, these patches can prove all over the body. It is an autoimmune disease in which the pigmentinducing cells are injured. There is no therapy for vitiligo, however there are few therapies, including ultraviolet light, cosmetic cover-ups or corticosteroid creams medications [2]. Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors, tyrosinase, TRP-1, TRP-2 and MITF [1]. Natural herbal extracts have powerful phytochemical properties which are now being exploited world over and there is a sudden surge in Ayurvedic or traditional uses of plant wealth in treatment of diseases like cancers, arthritis, sterility, psoriasis and diabetes. For the treatment of hypopigmentation or vitiligo, plant extracts have been used since time immemorial [3].However, still, there are no conclusive data available with regard to various tyrosinase stimulators on the mechanism of melanogenesis in different vertebrate species including human beings and reptiles. It is not clearly known that whether plant extracts induce increase arborisation of melanocyte dendrites or increase the number of melanin granules, or work through tyrosinase or any other signal transduction pathway in reactivating melanin polymerization within the pigment cells melanophores or melanocytes involving cellular receptor activation. We focus our attention on the use of melanogenesis stimulators from natural herbs. From the present review, it is become clear that the plant extracts play a major role against various hypopigmentary anomalies and this would provide an experimental basis for development of new pharmacotherapy’s against dermatological anomalies like treatment of vitiligo.